InterStim™

How InterStim™ therapy works for bladder and bowel control.

More than another pill. More than temporary relief.

Learn how InterStim™ system targets the sacral nerves that control bladder and bowel function, which may help you get your life back.

Overactive Bladder

Symptoms of Overactive bladder (OAB)

Bladder control problems affect tens of millions of people every day, and many people are reluctant to talk about it.

  • Urgency - uncontrollable urge to use the bathroom
  • Frequency - The need to urinate more than 8 times per day
  • Urge Incontinence - leakage accidents that occur before you reach the bathroom
  • Urinary Retention - Holding increasingly large amounts of urine
  • Stress Incontinence - Leaking when you sneeze, cough, laugh, or exercise
InterStim X neurostimulator

4.5 out of 10 1

adults don’t seek help for overactive bladder

54% 1

experience loss of confidence

49% 1

experience loss of self-esteem

45% 1

experience loss of intimacy

Relief from bladder and bowel symptoms delivered by the InterStim™ system

At Medtronic, we believe you deserve more from your bladder and bowel control therapy.

If you’ve tried medication and lifestyle changes and haven’t gotten the relief that you need, there is another option.

Our therapies work differently

When more conservative treatments fail, the InterStim™ system offers discreet, personalized relief that lets you get back to the activities you love.

Regain a life without limits with the InterStim™ system

Long lasting*¹

3X 4

greater quality of life than medications among bladder patients.

Small and powerful

84% *,‡,5

satisfaction among those who use InterStim.

Safe and proven¹-³

375K+

Patients implanted over 25 years.

How the InterStim™ system works

Where more conservative treatments target the bladder and bowel muscles, the InterStim™ system targets the sacral nerves that control bladder and bowel function.⁶,⁷ Targeting this communication may help restore* proper function.

  • Is clinically proven to reduce accidents¹-³
  • Is reported to significantly improve quality of life (lifestyle, ability to cope, embarrassment, and depression)¹-³
  • Allows you to get full-body§ MRI scans if you need them
  • Has been used to treat more than 375,000 patients worldwide
  • Is safe and minimally invasive¹-³
The urinary system connected with the InterStim X device

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FAQ about bladder and bowel control therapy

Delivered by the InterStim™ sacral neuromodulation system

Please review

Important Safety Information

Medtronic bladder control therapy delivered by the InterStim™ system treats urinary retention (inability to completely empty the bladder) and the symptoms of overactive bladder, including urinary urge incontinence (leakage) and significant symptoms of urgency-frequency. It should be used after you have tried other treatments such as medications and behavioral therapy and they have not worked, or you could not tolerate them. This therapy is not intended for patients with a urinary blockage.

Safety and effectiveness have not been established for pregnancy and delivery; patients under the age of 16; or for patients with neurological disease origins.

Medtronic bowel control therapy delivered by the InterStim™ system treats chronic fecal incontinence (an accident or leaking involving stool). It should be used after you have tried other treatments such as medications and dietary modifications and they have not worked, or if you are not a candidate for them.

Safety and effectiveness have not been established for pregnancy and delivery; patients under the age of 18; or for patients with progressive, systemic neurological diseases.

Medtronic bladder control therapy and Medtronic bowel control therapy: You must demonstrate an appropriate response to the evaluation to be a candidate. You cannot have diathermy (deep heat treatment from electromagnetic energy) if you have an InterStim™ device.

In addition to risks related to surgery, complications can include pain at the implant sites, new pain, infection, lead (thin wire) movement/migration, device problems, interactions with certain other devices or diagnostic equipment such as MRI, undesirable changes in urinary or bowel function, and uncomfortable stimulation (sometimes described as a jolting or shocking feeling).

This therapy is not for everyone. This treatment is prescribed by your doctor. Please talk to your doctor to decide whether this therapy is right for you. Your doctor should discuss all potential benefits and risks with you. Although many patients may benefit from the use of this treatment, results may vary. For further information, please call Medtronic at 800-328-0810 and/or consult the Medtronic website at medtronic.com.

United States Rx only. Rev 0517.

* Restoration of function is defined as a 50 percent or greater reduction in your troublesome bladder or bowel symptoms from baseline.

† Under expected therapy settings and telemetry use.

‡ Anticholinergic/antimuscarinic medication. Statistics reflect OAB patients.

§ Under certain conditions; see approved labeling for details. Patients with InterStim™ SureScan™ MRI leads only.

InterStim™ therapy overview references

  1. Siegel S, Noblett K, Mangel J, et al. Five-year follow-up results of a prospective, multicenter study of patients with overactive bladder treated with sacral neuromodulation. J Urol. 2018;199(1), 229-236.
  2. Medtronic InterStim Therapy Clinical Summary (2018).
  3. Hull T, Giese C, Wexner SD, et al. Long-term durability of sacral nerve stimulation therapy for chronic fecal incontinence. Dis Colon Rectum. 2013;56(2):234-245.
  4. Siegel S, Noblett K, Mangel J, et al. Results of a prospective, randomized, multicenter study evaluating sacral neuromodulation with InterStim therapy compared to standard medical therapy at 6-months in subjects with mild symptoms of overactive bladder. Neurourol Urodyn. 2015;34:224-230.
  5. Foster RT, Anoia EJ, Webster GD, Amundsen CL. In patients undergoing neuromodulation for intractable urge incontinence a reduction in 24-hr pad weight after the initial test stimulation best predicts long-term patient satisfaction. Neurourol Urodyn. 2007;26(2):213-217.
  6. Patton V, Wiklendt L, Arkwright JW, et al. The effect of sacral nerve stimulation on distal colonic motility in patients with fecal incontinence. Br J Surg. 2013;100(7):959-968.
  7. Leng WW, Morrisroe SN. Sacral nerve stimulation for the overactive bladder. Urol Clin N Am. 2006;33:491-501.

InterStim™ FAQ references

  1. Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20(6):327-336.
  2. Whitehead WE, Borrud L, Goode PS, et al. Fecal incontinence in US adults: epidemiology and risk factors. Gastroenterol. 2009;137(2):512-517.
  3. Ditah I, Devaki P, Luma HN et al. Prevalence, trends, and risk factors for fecal incontinence in United States adults, 2005-2010. Clin Gastroenterol Hepatol. 2014;12:636-643.
  4. Griffiths D, Derbyshire S, Stenger A, Resnick N. Brain control of normal and overactive bladder. J Urol. 2005;174:1862-1867.
  5. Patton V, Wiklendt L, Arkwright JW, et al. The effect of sacral nerve stimulation on distal colonic motility in patients with fecal incontinence. Br J Surg. 2013;100(7):959-968.
  6. Leng WW, Morrisroe SN. Sacral nerve stimulation for the overactive bladder. Urol Clin N Am. 2006;33:491-501.
  7. Chancellor MB, Chartier-Kastler EJ. Principles of sacral nerve stimulation (SNS) for the treatment of bladder and urethral sphincter dysfunctions. Neuromod. 2000;3(1):15-26.
  8. Siegel S, Noblett K, Mangel J, et al. Five-year follow-up results of a prospective, multicenter study of patients with overactive bladder treated with sacral neuromodulation. J Urol. 2018;199(1), 229-236.
  9. Medtronic InterStim™ therapy clinical summary (2018).
  10. Hull T, Giese C, Wexner SD, et al. Long-term durability of sacral nerve stimulation therapy for chronic fecal incontinence. Dis Colon Rectum. 2013;56(2):234-245.
  11. Siegel S, Noblett K, Mangel J, et al. Results of a prospective, randomized, multicenter study evaluating sacral neuromodulation with InterStim™ therapy compared to standard medical therapy at six months in subjects with mild symptoms of overactive bladder. Neurourol Urodyn. 2015;34:224-230.
  12. Yeaw J, Benner J, Walt JG et al. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm. 2009:15(9):724-736.

Overactive bladder statistics reference

  1. Leede Research, “Views on OAB: A Study for the National Association of Continence.” December 16, 2015.